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Transcendental aspects of architectural design as factors of sustainability
Volnohradský, Radan ; Peřinková, Martina (referee) ; Loutocká, Vlasta (referee) ; Uřídilová, Marcela (referee) ; Urbášková, Hana (advisor)
This thesis deals with complex processes, relationships and phenomena which go beyond the assumed and accepted materialistic perception of the world in general and the process of architectural design specifically. It clarifies and actually redefine the sustainability from a point of higher universal principles forming our environment. At the beginning this thesis presents an extensive knowledge base of existing holistic design systems including Feng-shui, sacred geometry, geomancy or numerology. The purpose is to build and establish a solid foundation for understanding and further research as well as objectively interpreting lesser known topics as a whole. On the basis of intersecting information through the above mentioned topics we specify the hypothesis which proposes the pre-existence of one unifying design matrix of harmonic structures in architecture. The structure of its verification takes us from an analysis of the science of human perception to systems of self-similar contextual references of animated and inanimated forms. These systems of emergent form and flow are basically known as fractals, and could be expressed in both mathematical and geometrical languages. The thesis research then consists of analysing chosen examples of urban and architectural scale in sense of fractality, symbolism and geometrical matrices. We include and integrate the research of associated and relevant phenomena in pedagogical practice, and a case study of the application of fractals in development of a chosen town. From the results of this thesis we abstract five non-dogmatic guidelines or tenets for architectural design; which are supported by experimental verification on some of the author´s buildings. These tenets stand as pillars of implosive architecture. This kind of architecture in context of transcendental overlaps means a possibility of how to bring our anthropogenic environment closer to the natural and harmonic code of the Universe.
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Vitality in the architectonic environment
Eyer, David ; Horáček, Martin (referee) ; Hudec, Mojmír (referee) ; Kyselka, Mojmír (referee) ; Žabičková, Ivana (advisor)
More and more research studies are being conducted on the quality of architectural space as a factor affecting our mental, social and physical health. In the past, this topic was often overlooked in its complexity. The establishment of the specialized fields of building biology, biophilic architecture and the works of Christopher Alexander and Nikos Salingaros now allow us to consider various facets of this subject. This dissertation aims to analyse the topic of vitality in architectural space by studying the abilities and perceptions of its users. Therefore its aim is not to develop a new theory of “vitality-enhancing architectural space”, but to describe how this phenomenon is perceived by the users themselves. Users can provide feedback on which features of architectural space they see as the most important for the feeling of vitality. These features have been hierarchically organized based on their perceived importance, analysed and described in detail to allow their relatively easy application in practice. This dissertation will also allow a comparison with other existing works on the studied topic.
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Fractal aspects of flow and consolidation behaviour of microcrystalline cellulose.
Šofranková, Alexandra ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
7 2 Abstract Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Alexandra Šofranková Title of Thesis: Fractal aspects of flow and consolidation behaviour of microcrystalline cellulose The object of this diploma thesis was to study the flow and consolidation characteristics of three types of microcrystalline cellulose. The granulometric characteristics, including the linear fractal dimension, were estimated using the optical microscopy. The bulk and tapped density, the angle of repose and the flow rate through an orifice of the hopper were evaluated. True density of the materials and the porosity of a loose powder bed were determined by helium pyknometry. The changes of density by the gravity consolidation were studied; the relationship of Hausner ratio on the number of taps describes best the differences in the consolidation behaviour of the substances. Modelling the consolidation kinetic by the exponential law allowed to determine the parameter N1/2, which shows the number of taps needed to reach one half of the powder volume reduction. The values of N1/2 within a range of 6,9-18 correlated well with the particle size of the used types of microcrystalline cellulose.
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Homogenization of powder blends using a Turbula mixer.
Litošová, Martina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
1 Abstract Charles University, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph. D. Consultant PharmDr. Karel Palát, CSc., Mgr. Žofie Trpělková Student: Martina Litošová Title of Thesis: Homogenization of powder blends using a Turbula mixer. In this experimental work, the influencing of the homogeneity of the powder mixture of acetylsalicylic acid (ASA) and microcrystalline cellulose (Avicel PH102) due to the rotational speed of the mixing container in a range of 23−101 rpm, and the mixing time was studied using the Turbula shaker mixer. Within time interval 2-62 minutes, the content of ASA in samples was measured by near-infrared spectrometry. The expression of standard deviation was used to evaluate the homogeneity of samples. The best results were detected at a rotational speed of 34 rpm within time interval of 14−30 min.
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The study of influence of the measurement method on static angle of repose of free-flowable excipients
Mrázková, Aneta ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Žofie Trpělková Student: Aneta Mrázková Title of Thesis: The study of influence of the measurement method on static angle of repose of free-flowable excipients. Good flow and consolidation properties of powders represent significant characteristics of pharmaceutical excipients They are important for manufacturing of powders into solid dosage forms. Flow behavior of 6 free flowing excipients was evaluated in this diploma thesis. The main target was a study of the influence of the masurement method and the orifice size of a conical hopper on static angle of repose (AOR). The automatic tester and the prototype for measuring AOR having orifice sizes in a range of 6-15 mm were used for the measurement. A significant difference between the results of these two methods (P <0.01) was observed. The decrease in AOR was detected when increased the orifice diameter, the effect was significant (P <0.01) only in automatic tester for two out of six measured powders. Surprisingly, the significant influence of the orifice size on AOR was registered for a sweetener Palatinose with protype equipment.
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Study of bulk and consolidation properties of size fractions of anhydrous lactose
Dostálová, Eliška ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Ing. Hana Hurychová Student: Eliška Dostálová Title of Thesis: Study of bulk and consolidation properties of size fractions of anhydrous lactose The bulk and consolidation behaviour of pharmaceutical excipients belong to their important properties. Properties of five size fractions of anhydrous lactose having the particle size in the range of 1-400 µm were studied in this thesis. The measurement was carried out by using static and dynamic pharmacopoeial methods. The bulk density and the tapped density, the angle of repose were evaluated as well as the true density of particles by using the gas pycnometry. The mass flow rate through the orifice of a model conical hopper by the force of gravity was estimated for the individual size fractions. The discharge rate through the orifice having the diameter in a range of 0.6-1.5 cm was modelled with the Beverloo et al and Jones & Pilpel power regression equations; the precision of the flow rate prediction was about 3 %. The best bulk properties were detected for the particle size fraction 246 µm. The results of the evaluation of the consolidation dynamic during the tapping of powder bed permitted...
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Study of consolidation behaviour of lactose and its blends
Bérešová, Michaela ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Michaela Bérešová Title of Thesis: Study of consolidation behaviour of lactose and its blends Flow behaviour and consolidation properties are important characteristics of the powder substances. The aim of this thesis was to evaluate these properties for four types of lactose with different particle size and for the mixtures of two lactoses with different flow properties. The density and porosity of the powder bed and their changes during the consolidation due to the gravitational tapping were studied. The non-linear regression equation was used to describe the consolidation process for the samples and the parameter N½, which expresses the number of taps needed to achieve a half reduction of a powder bed volume. The value of N½ increased with the decrease in the particle size.
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The study of influence of the measurement method on static angle of repose of free-flowable excipients
Mrázková, Aneta ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Žofie Trpělková Student: Aneta Mrázková Title of Thesis: The study of influence of the measurement method on static angle of repose of free-flowable excipients. Good flow and consolidation properties of powders represent significant characteristics of pharmaceutical excipients They are important for manufacturing of powders into solid dosage forms. Flow behavior of 6 free flowing excipients was evaluated in this diploma thesis. The main target was a study of the influence of the masurement method and the orifice size of a conical hopper on static angle of repose (AOR). The automatic tester and the prototype for measuring AOR having orifice sizes in a range of 6-15 mm were used for the measurement. A significant difference between the results of these two methods (P <0.01) was observed. The decrease in AOR was detected when increased the orifice diameter, the effect was significant (P <0.01) only in automatic tester for two out of six measured powders. Surprisingly, the significant influence of the orifice size on AOR was registered for a sweetener Palatinose with protype equipment.
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On multifractality and predictability of financial time series
Heller, Michael ; Krištoufek, Ladislav (advisor) ; Vácha, Lukáš (referee)
The aim of this thesis is to examine an empirical relationship between multifrac- tality of financial time series and its returns. We approach the multifractality of a given time series as a measure of its complexity. Multifractal financial time series exhibit repeating self-similar patterns. Multifractality could be a good predictor of stock returns or a factor which can be used in asset pricing. We expected that capturing the complexity of a given time series by a model, a positive or a negative risk premia for investing into "more multifractal assets" could be found. Daily prices of 31 stock indices and daily returns of 10-years US government bonds were downloaded. All the data were recorded between 2012 and 2021. After estimation the multifractal spectra, applying MF-DFA method, of all stock indices, we ordered all stock indices from the lowest to the most multifractal. Then, we constructed a "multifractal portfolio" holding a long position in the 7 most multifractal and holding a short position in the 7 least multifractal stock indices. Fama-MacBeth regression with market risk premia and multifractal variable as independent variables was applied. Multi- fractality in all examined financial time series was found. We also found a very low negative risk premia for holding "a multifractal...
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The study of influence of the measurement method on static angle of repose of free-flowable excipients
Mrázková, Aneta ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical technology Supervisor: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Žofie Trpělková Student: Aneta Mrázková Title of Thesis: The study of influence of the measurement method on static angle of repose of free-flowable excipients. Good flow and consolidation properties of powders represent significant characteristics of pharmaceutical excipients They are important for manufacturing of powders into solid dosage forms. Flow behavior of 6 free flowing excipients was evaluated in this diploma thesis. The main target was a study of the influence of the masurement method and the orifice size of a conical hopper on static angle of repose (AOR). The automatic tester and the prototype for measuring AOR having orifice sizes in a range of 6-15 mm were used for the measurement. A significant difference between the results of these two methods (P <0.01) was observed. The decrease in AOR was detected when increased the orifice diameter, the effect was significant (P <0.01) only in automatic tester for two out of six measured powders. Surprisingly, the significant influence of the orifice size on AOR was registered for a sweetener Palatinose with protype equipment.
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